In this paper, the authorship team led by Dr Robyn Littlewood aimed to describe the development and integration of a Children’s Health Service and System Research (HSSR) Strategy in Children’s Health Queensland. This was the first known paediatric HSSR strategy developed and integrated within a large dedicated paediatric health system. Findings will guide global paediatric healthcare systems to prioritise HSSR in their local setting to optimise health service delivery and patient outcomes.